Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia,
Mol Biol Rep. 2014 Mar;41(3):1731-40. doi: 10.1007/s11033-014-3022-z. Epub 2014 Jan 17.
Obesity, commonly measured as body mass index (BMI), has been on a rapid rise around the world and is an underlying cause of several chronic non-communicable diseases, including type 2 diabetes mellitus (T2DM). In addition to the environmental factors, genetic factors may also contribute to the ongoing obesity epidemic in Saudi Arabia. This study investigated the association between variants of 36 previously established T2DM SNPs and obesity phenotypes in a population of Saudi subjects. Study subjects consisted of 975 obese (BMI: ≥30), 825 overweight (25-30) and 423 lean controls (18-25) and of these 927 had a history of T2DM. Subjects were genotyped for 36 SNPs, which have been previously proved to be T2DM linked, using the KASPar method and the means of BMI and waist circumference (WC) corresponding to each of the genotypes were compared by additive, recessive and dominant genetic models. Five and seven of 36 T2DM-related SNPs were significantly associated with the BMI and WC, respectively. Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC. Variant of SNP rs10440833 was significantly associated with BMI in T2DM group of both males [OR = 1.8 (1.0, 3.3); P = 0.04] and females [OR = 2.0 (1.0, 3.9); P = 0.04]. Genetic risk scores explained 19 and 14% of WC and hip size variance in this population. Variants of a number of established T2DM related SNPs were associated with obesity phenotypes and may be significant hereditary factors in the pathogenesis of T2DM.
肥胖通常用体重指数（BMI）来衡量，在世界各地呈快速上升趋势，是包括 2 型糖尿病（T2DM）在内的几种慢性非传染性疾病的根本原因。除了环境因素外，遗传因素也可能导致沙特阿拉伯持续的肥胖流行。本研究调查了 36 个先前确定的 T2DM SNP 变体与沙特人群肥胖表型之间的关联。研究对象包括 975 名肥胖者（BMI：≥30）、825 名超重者（25-30）和 423 名正常体重者（18-25），其中 927 名有 T2DM 病史。采用 KASPar 法对 36 个 SNP 进行基因分型，这些 SNP 先前已被证明与 T2DM 相关，比较了每种基因型的 BMI 和腰围（WC）平均值，采用加性、隐性和显性遗传模型。36 个与 T2DM 相关的 SNP 中有 5 个和 7 个与 BMI 和 WC 分别显著相关。在对照组中，SNP rs7903146、rs1552224 和 rs11642841 以及 T2DM 组中的 rs7903146 与 BMI 和 WC 均显著相关。SNP rs10440833 变体在男性 [OR=1.8（1.0，3.3）；P=0.04]和女性 [OR=2.0（1.0，3.9）；P=0.04]T2DM 组中与 BMI 显著相关。在该人群中，遗传风险评分解释了 19%和 14%的 WC 和臀围变异。一些已确定的与 T2DM 相关的 SNP 变体与肥胖表型相关，可能是 T2DM 发病机制中的重要遗传因素。
