Tonge D A
Q J Exp Physiol Cogn Med Sci. 1978 Jan;63(1):39-47. doi: 10.1113/expphysiol.1978.sp002413.
A sublethal dose of a post-synaptic blocking fraction of Naja siamensis venom was injected into the soleus muscle of the mouse inhibiting neuromuscular transmission for 2-3 days. The paralysed soleus muscle behaved as if denervated, developing extra-junctional sensitivity to acetylcholine and accepting innervation by an implanted foreign nerve. Since the only known action of the post-synaptic blocking fraction of this venom is due to its affinity to acetylcholine receptors, the results suggest that the spread in the sensitivity of muscle fibres to acetylcholine and their ability to accept a foreign nerve is a consequence of neuromuscular blockade.
将亚致死剂量的眼镜蛇毒突触后阻断部分注射到小鼠比目鱼肌中，可抑制神经肌肉传递2至3天。麻痹的比目鱼肌表现得如同去神经支配一般，对乙酰胆碱产生接头外敏感性，并接受植入的异体神经的支配。由于已知这种毒液的突触后阻断部分的唯一作用是因其对乙酰胆碱受体的亲和力，结果表明肌肉纤维对乙酰胆碱敏感性的扩散及其接受异体神经的能力是神经肌肉阻断的结果。
