单腿：海藻糖单酯以 Mincle 依赖的方式激活巨噬细胞。
On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner.
机构信息
School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand); Malaghan Institute of Medical Research, P. O. Box 7060, 6242 Wellington (New Zealand).
出版信息
Chembiochem. 2014 Feb 10;15(3):382-8. doi: 10.1002/cbic.201300674. Epub 2014 Jan 16.
The C22 and C26 trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a Mincle-dependent manner. The activities of the monoesters paralleled those of their diester counterparts, and both mono- and diesters could activate the immune response in the absence of priming. This is the first time that trehalose monoesters have been found to activate macrophages, and these studies thus provide an important framework for the rational design of other Mincle agonists.
C22 和 C26 海藻糖单酯，每个都含有单个酰基链，以良好的总收率合成，并发现以 Mincle 依赖性方式激活巨噬细胞。单酯的活性与它们的二酯对应物的活性相平行，并且单酯和二酯都可以在没有引发的情况下激活免疫反应。这是首次发现海藻糖单酯能够激活巨噬细胞，因此这些研究为合理设计其他 Mincle 激动剂提供了重要框架。
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