Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN , USA .
Connect Tissue Res. 2014 Jan-Feb;55(1):8-12. doi: 10.3109/03008207.2013.867337.
The study of collagen IV has benefited greatly from the seminal work conducted by Arthur Veis and colleagues over three decades ago. Through a series of electron microscopy studies focused on lens basement membrane, an appreciation was gained for the distinct network-forming properties of collagen IV. Veis correctly suggested that network assembly is a phenomenon of the non-collagenous termini of the molecule. This review seeks to document how the field advanced following these seminal conclusions, including recent discoveries regarding the molecular reinforcement of networks that support Veis' conclusions.
三十多年前,Arthur Veis 及其同事进行的开创性工作极大地促进了对 IV 型胶原的研究。通过一系列专注于晶状体基底膜的电子显微镜研究,人们对 IV 型胶原独特的网络形成特性有了更深入的了解。Veis 正确地提出,网络组装是分子非胶原末端的一种现象。本综述旨在记录该领域在这些开创性结论之后的发展情况,包括最近关于支持 Veis 结论的网络分子增强的发现。