Evans-Marin Heather L, Cong Yingzi
Department of Microbiology and Immunology, University of Texas Medical Branch, 4.142C Medical Research Building, 301 University Blvd, Galveston, TX 77555-1019, USA.
Inflamm Allergy Drug Targets. 2014 Feb;13(1):65-73. doi: 10.2174/1871528113666140118202140.
The intestines harbor over trillions of commensal bacteria, which co-evolve and form a mutualistic relationship with the host, with microbial-host interaction shaping immune adaption and bacterial communities. The intestinal microbiota not only benefits the host and contributes to the maintenance of intestinal homeostasis, but also causes chronic intestinal inflammation under certain conditions. Thus, understanding the microbiota regulation of inflammatory bowel disease (IBD) will provide great insights into the pathogenesis of IBD as well as potential therapeutics for IBD patients.
肠道中寄居着数万亿计的共生细菌，它们与宿主共同进化并形成一种互利共生关系，微生物与宿主的相互作用塑造了免疫适应和细菌群落。肠道微生物群不仅有益于宿主并有助于维持肠道内环境稳定，而且在某些情况下还会引发慢性肠道炎症。因此，了解微生物群对炎症性肠病（IBD）的调节作用将为深入了解IBD的发病机制以及为IBD患者提供潜在治疗方法提供重要线索。
