Babickova Janka, Gardlik Roman
Janka Babickova, Roman Gardlik, Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.
World J Gastroenterol. 2015 Oct 28;21(40):11321-30. doi: 10.3748/wjg.v21.i40.11321.
The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition, the immune system and environmental factors. In the recent years, metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review, we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD, host-microbe interactions and therapeutic possibilities using bacteria in IBD. Moreover, an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.
肠道微生物群是宿主与其微生物之间相互作用的动态系统。在生理条件下，存在着良好的平衡和互利关系。这种平衡的破坏是炎症性肠病（IBD）的一个标志。目前尚不完全清楚微生物群的改变是IBD的结果还是原因。IBD的发病机制被认为是遗传易感性、免疫系统和环境因素之间的复杂相互作用。近年来，对人类微生物群的宏基因组研究提供了有用的数据，有助于拼凑IBD之谜。在这篇综述中，我们总结并讨论了关于IBD中肠道微生物群组成、宿主-微生物相互作用以及使用细菌治疗IBD的可能性的当前知识。此外，还展望了噬菌体在IBD发病机制和治疗中的可能作用。
