miRNA-34a：在癌症和心血管疾病中的作用。
MicroRNA-34a: role in cancer and cardiovascular disease.
机构信息
Department of Respiratory Diseases, Thoracic Disease Diagnosis and Treatment Center, The First Affiliated Hospital of College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China.
出版信息
Curr Drug Targets. 2014 Apr;15(4):361-73. doi: 10.2174/1389450115666140120102935.
Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.
小非编码 microRNAs（miRNAs）在转录后和翻译水平上调节基因表达。失调的 miRNAs 参与多种疾病，包括癌症和心血管疾病。miR-34a 是下调多种癌症中最具抑癌作用的 microRNA 之一。它调节广泛涉及癌症起始、进展和转移的基因和途径。除了癌症，miR-34a 最近被发现作为心血管疾病的一个损害因素。在这篇综述中，我们强调了 miR-34a 在癌症和心血管疾病中的复杂作用，以及治疗潜力。
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