Lee E H, Lin H H, Yin H M
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Neurosci Lett. 1987 Sep 11;80(1):115-9. doi: 10.1016/0304-3940(87)90506-4.
Various types of stressors were given to different groups of animals to examine their effects on the mesostriatal and mesolimbic serotonergic pathways. Results indicate that shock-induced fighting experience preferentially decreased serotonin (5-HT) levels in the dorsal raphe and striatum, while air puff stimulation selectively lowered 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) contents in the median raphe and hippocampus. Both immobilization and light footshock stress have a more consistent effect on both serotonergic systems. These results suggest that different stressors have differential influences upon central 5-HT neurons and, other than anatomical differentiation, these serotonergic neurons are not homogeneous with respect to their responses to stress either.
给不同组的动物施加各种类型的应激源，以检查它们对中脑纹状体和中脑边缘5-羟色胺能通路的影响。结果表明，电击诱导的战斗经历优先降低了中缝背核和纹状体中的5-羟色胺（5-HT）水平，而吹气刺激则选择性地降低了中缝正中核和海马体中的5-HT和5-羟吲哚乙酸（5-HIAA）含量。固定和轻度电击应激对这两种5-羟色胺能系统都有更一致的影响。这些结果表明，不同的应激源对中枢5-HT神经元有不同的影响，并且除了解剖学差异外，这些5-羟色胺能神经元在对应激的反应方面也不是同质的。
