Samuel C E
University of California, Department of Biological Sciences, Santa Barbara 93106.
Prog Clin Biol Res. 1987;246:209-20.
Results of cellular and molecular analyses of type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) human interferons demonstrate that these proteins differentially regulate the expression of certain cellular genes and induce mechanistically distinct antiviral states in human cells. Although none of the human genes whose expression is regulated by IFN have yet been localized to human chromosome 21, the localization of the receptor for the type I IFNs to chromosome 21 may have important consequences with regard to the functions of the interferon system in Down Syndrome individuals.
对I型（干扰素α和干扰素β）和II型（干扰素γ）人干扰素进行细胞和分子分析的结果表明，这些蛋白质对某些细胞基因的表达有不同的调节作用，并在人细胞中诱导出机制上不同的抗病毒状态。虽然其表达受干扰素调节的人类基因中，尚未有任何一个被定位于人类21号染色体，但I型干扰素受体定位于21号染色体这一情况，可能对唐氏综合征个体中干扰素系统的功能具有重要影响。
