Okuda Hirofumi, Matsushima Shigeru, Sugiura Hideshi, Yamada Kenji, Hamada Shunsuke, Nishida Yoshihiro, Ishiguro Naoki
Aichi Cancer Center Hospital, Orthopedic Surgery.
Aichi Cancer Center Hospital, Radiology.
Magn Reson Imaging. 2014 Apr;32(3):206-10. doi: 10.1016/j.mri.2013.12.004. Epub 2013 Dec 18.
Equivalent cross-relaxation rate imaging (ECRI) is an MRI technique used to evaluate qualitative changes in protein-water interactions. We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors.
Institutional Review Board approval was obtained and all patients provided informed consent. Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n=22), atypical lipomatous tissue/well-differentiated liposarcoma (ALT/WDL; n=9), myxoid/round cell liposarcoma (MyL; n=6), and dedifferentiated liposarcoma (DDL; n=3), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed.
Mean ECR values of lipomas, ALT/WDL, and subcutaneous fat were low, and those of MyL and DDL were high. Mean ECR values of MyL and DDL were significantly higher than those of ALT/WDL. The cut-off value was 5.1%. There was a positive correlation between ECR value, pathological grade, and cell density in adipocytic tumors.
The ECR value positively correlates with pathological grade and cell density of adipocytic tumors. Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors.
等效交叉弛豫率成像（ECRI）是一种用于评估蛋白质-水相互作用定性变化的磁共振成像（MRI）技术。我们旨在前瞻性评估ECRI在脂肪细胞性肿瘤分类中的应用价值。
获得机构审查委员会批准，所有患者均签署知情同意书。研究参与者包括40例脂肪细胞性肿瘤患者，其中脂肪瘤患者22例、非典型脂肪瘤性组织/高分化脂肪肉瘤（ALT/WDL）患者9例、黏液样/圆细胞脂肪肉瘤（MyL）患者6例、去分化脂肪肉瘤（DDL）患者3例，以及20例对照患者，对其臀部或大腿的皮下脂肪进行分析。
脂肪瘤、ALT/WDL和皮下脂肪的平均ECR值较低，而MyL和DDL的平均ECR值较高。MyL和DDL的平均ECR值显著高于ALT/WDL。截断值为5.1%。脂肪细胞性肿瘤的ECR值与病理分级和细胞密度呈正相关。
ECR值与脂肪细胞性肿瘤的病理分级和细胞密度呈正相关。我们的研究结果表明，ECRI是术前评估脂肪细胞性肿瘤的一种有用方法。
