Peabody C A, Whiteford H A, Warner M D, Faull K F, Barchas J D, Berger P A
Department of Psychiatry, Vanderbilt School of Medicine, Nashville, TN.
Psychiatry Res. 1987 Sep;22(1):21-8. doi: 10.1016/0165-1781(87)90046-1.
A thyrotropin-releasing hormone (TRH) stimulation test was performed in 52 male inpatients with major depressive disorder. Twenty-nine percent of the 52 subjects had a delta thyroid-stimulating hormone (delta TSH) less than 5 microU/ml. The cerebrospinal fluid (CSF) amine metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA), were measured in 29 subjects, and a dexamethasone suppression test (DST) was performed in 48 subjects. Of the three CSF amine metabolites, only MHPG correlated significantly with baseline TSH and none correlated with delta TSH. The baseline TSH correlated positively with the TSH response at 30 minutes. Neither baseline TSH nor delta TSH correlated with cortisol levels before or after dexamethasone. The correlation between CSF MHPG and serum TSH suggests a relationship between central norepinephrine and baseline TSH.
对52名男性重度抑郁症住院患者进行了促甲状腺激素释放激素（TRH）刺激试验。52名受试者中有29%的促甲状腺激素变化量（ΔTSH）低于5微国际单位/毫升。对29名受试者测量了脑脊液（CSF）胺类代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）、高香草酸（HVA）和5-羟吲哚乙酸（5HIAA），并对48名受试者进行了地塞米松抑制试验（DST）。在这三种脑脊液胺类代谢产物中，只有MHPG与基线TSH显著相关，而与ΔTSH均无相关性。基线TSH与30分钟时的TSH反应呈正相关。基线TSH和ΔTSH与地塞米松给药前后的皮质醇水平均无相关性。脑脊液MHPG与血清TSH之间的相关性表明中枢去甲肾上腺素与基线TSH之间存在关联。
