P Kauppi, M Kuokkanen, K Kukkonen, T Laitinen, M Kuitunen
Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
The Finnish Institute for Health and Welfare, Helsinki, Finland.
Allergol Immunopathol (Madr). 2014 Nov-Dec;42(6):560-7. doi: 10.1016/j.aller.2013.10.001. Epub 2014 Jan 14.
Neuropeptide S Receptor (NPSR1) gene has been associated with multiple allergic phenotypes in several patient populations.
We analysed the effect of the NPSR1 genotypes in the development of asthma, rhinitis, eczema, or food allergy in children randomly receiving either probiotic or placebo treatment.
796 children born to families at high risk for allergic diseases were examined by a paediatrician at the age of three months, six months, two years, and five years. Asthma, rhinitis, eczema, and food allergy were diagnosed according to international guidelines. Treatment with probiotics (double-blinded and placebo controlled) was begun with mothers at 35 weeks of gestation age and continued after the birth of infants up to the age of six months. Association and additive inheritance models were used in genetic analyses.
Distribution of the hopo546333 was suggestive in the group of patients with atopic eczema at two years. The hopo546333_G was found more often in those with eczema in the placebo group (p=0.048, after Bonferroni correction) and the hopo546333_A was found more often in those with eczema and probiotics compared to those with eczema and placebo treatment. None of the NPSR1 tagging SNPs was associated with asthma, IgE-mediated asthma, or sensitisation. Allergic disease in both parents doubled the risk for IgE-mediated allergic disease (OR 2.1).
The NPSR1 gene SNP hopo546333 showed a suggestive association for high IgE-associated atopic eczema at two years.
神经肽S受体（NPSR1）基因已在多个患者群体中与多种过敏表型相关联。
我们分析了NPSR1基因型对随机接受益生菌或安慰剂治疗的儿童哮喘、鼻炎、湿疹或食物过敏发生发展的影响。
796名出生于过敏性疾病高危家庭的儿童在3个月、6个月、2岁和5岁时由儿科医生进行检查。根据国际指南诊断哮喘、鼻炎、湿疹和食物过敏。益生菌治疗（双盲和安慰剂对照）在母亲孕龄35周时开始，并在婴儿出生后持续至6个月。遗传分析采用关联模型和加性遗传模型。
hopo546333在2岁患有特应性湿疹的患者组中分布具有提示性。在安慰剂组中，hopo546333_G在湿疹患者中更常见（p = 0.048，经Bonferroni校正后），与接受湿疹和安慰剂治疗的患者相比，hopo546333_A在接受湿疹和益生菌治疗的患者中更常见。NPSR1标签单核苷酸多态性均与哮喘、IgE介导的哮喘或致敏无关。父母双方患有过敏性疾病会使IgE介导的过敏性疾病风险增加一倍（比值比2.1）。
NPSR1基因单核苷酸多态性hopo546333在2岁时与高IgE相关的特应性湿疹存在提示性关联。
