成人干细胞龛：细胞和分子成分。
Adult stem cell niches: cellular and molecular components.
机构信息
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
出版信息
Curr Top Dev Biol. 2014;107:333-72. doi: 10.1016/B978-0-12-416022-4.00012-3.
As stem cells (SCs) in adult organs continue to be identified and characterized, it becomes clear that their survival, quiescence, and activation depend on specific signals in their microenvironment, or niche. Although adult SCs of diverse tissues differ by their developmental origin, cycling activity, and regenerative capacity, there appear to be conserved similarities regarding the cellular and molecular components of the SC niche. Interestingly, many organs house both slow-cycling and fast-cycling SC populations, which rely on the coexistence of quiescent and inductive niches for proper regulation. In this review we present a general definition of adult SC niches in the most studied mammalian systems. We further focus on dissecting their cellular organization and on highlighting recently identified key molecular regulators. Finally, we detail the potential involvement of the SC niche in tissue degeneration, with a particular emphasis on aging and cancer.
随着成年器官中的干细胞 (SCs) 不断被识别和表征，越来越明显的是，它们的存活、静止和激活取决于其微环境或生态位中的特定信号。尽管不同组织的成年干细胞在其发育起源、循环活性和再生能力方面存在差异，但在干细胞生态位的细胞和分子成分方面似乎存在保守的相似性。有趣的是，许多器官中都存在慢循环和快循环的干细胞群体，它们依赖于静止和诱导生态位的共存来进行适当的调节。在这篇综述中，我们对最受研究的哺乳动物系统中的成年干细胞生态位提出了一个一般定义。我们进一步专注于剖析它们的细胞组织，并强调最近发现的关键分子调节剂。最后，我们详细说明了干细胞生态位在组织退化中的潜在作用，特别强调了衰老和癌症。
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