Department of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University, 1838 Guangzhou North Road Guangzhou, Guangdong, People's Republic of China.
Shanghai East Hospital of Tongji University, Shang Hai, China.
Stem Cell Rev Rep. 2022 Aug;18(6):2016-2027. doi: 10.1007/s12015-022-10411-2. Epub 2022 Jul 18.
Mesenchymal stem cells (MSCs) are known for their self-renewal and multi-lineage differentiation potential, with these cells often being evaluated in the regulation and maintenance of specific cellular niches including those of the hair follicle. Most mesenchymal stem cells in the hair follicles are housed in the dermal papilla (DP) and dermal sheath (DS), with both niches characterized by a broad variety of cellular subsets. However, while most previous studies describing the hair follicle mesenchymal niche treated all DP and DS cells as Hair Follicle Mesenchymal Stem Cells (HF-MSCs), the high number of cellular subsets would suggest that these cells are actually too heterogenous for such a broad definition. Given this we designed this study to evaluate the differentiation processes in these cells and used this data to create a new set of classifications for DP and DS cells, dividing them into "hair follicle mesenchymal stem cells (HF-MSCs)", "hair follicle mesenchymal progenitor cells (HF-MPCs)", and "hair follicle mesenchymal functional cells (HF-MFCs)". In addition, those cells that possess self-renewal and differentiation were re-named hair follicle derived mesenchymal multipotent cells (HF-MMCs). This new classification may help to further our understanding of the heterogeneity of hair follicle dermal cells and provide new insights into their evaluation.
间充质干细胞（MSCs）以其自我更新和多能分化潜能而闻名，这些细胞经常被评估在特定细胞龛（包括毛囊）的调节和维持中的作用。毛囊中的大多数间充质干细胞位于真皮乳头（DP）和真皮鞘（DS）中，这两个龛位都具有广泛的细胞亚群。然而，尽管大多数描述毛囊间充质龛的先前研究将所有 DP 和 DS 细胞都视为毛囊间充质干细胞（HF-MSCs），但如此多的细胞亚群表明这些细胞实际上过于异质化，不能用如此广泛的定义来描述。有鉴于此，我们设计了这项研究来评估这些细胞的分化过程，并利用这些数据为 DP 和 DS 细胞创建了一组新的分类，将它们分为“毛囊间充质干细胞（HF-MSCs）”、“毛囊间充质祖细胞（HF-MPCs）”和“毛囊间充质功能细胞（HF-MFCs）”。此外，那些具有自我更新和分化能力的细胞被重新命名为毛囊来源的间充质多能细胞（HF-MMCs）。这种新的分类方法可能有助于我们进一步了解毛囊真皮细胞的异质性，并为它们的评估提供新的见解。
