Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia.
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Cytokine Growth Factor Rev. 2014 Apr;25(2):235-43. doi: 10.1016/j.cytogfr.2013.12.012. Epub 2013 Dec 25.
Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.
肠道细菌病原体，如肠致病性大肠杆菌、沙门氏菌和志贺氏菌，控制着人类肠道细胞中的炎症和凋亡信号，从而建立感染、复制和传播到其他宿主。这些病原体通过将毒力效应蛋白直接转运到宿主细胞质中来操纵宿主细胞信号，从而靶向各种信号通路。死亡受体，如 TNFR1、FAS 和 TRAIL-R，诱导对清除病原体至关重要的信号级联反应，因此是病原体抑制的主要靶点。这篇综述重点介绍了肠道细菌病原体如何抑制死亡受体信号，从而抑制炎症和防止细胞凋亡。
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