胸主动脉夹层患者的交感神经过度活跃和主动脉交感神经增生
Sympathetic hyperactivity and aortic sympathetic nerve sprouting in patients with thoracic aortic dissection.
作者信息
Zhipeng Hu, Zhiwei Wang, Lilei Yu, Hao Zhang, Hongbing Wu, Zongli Ren, Hao Chen, Xiaoping Hu
机构信息
Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
出版信息
Ann Vasc Surg. 2014 Jul;28(5):1243-8. doi: 10.1016/j.avsg.2013.11.016. Epub 2014 Jan 16.
BACKGROUND
To determine the yet unknown relation between thoracic aortic dissection (TAD) and sympathetic nervous system activity.
METHODS
Variables such as electrocardiography, blood pressure, respiratory activity, postganglionic muscle sympathetic nerve activity (MSNA), plasma norepinephrine, tyrosine hydroxylase-positive nerve fiber density, and growth-associated protein 43-positive nerve fiber density were detected and statistically analyzed.
RESULTS
TAD Patients showed a significant lower R-R interval variance and higher blood pressure, heart rate, respiratory rate, MSNA, plasma norepinephrine (reflecting elevated sympathetic nervous system [SNS] activity), higher tyrosine hydroxylase, growth-associated protein 43-positive nerve fiber density (reflecting sympathetic sprouting and innervation) than those of the control group.
CONCLUSIONS
In TAD patients, both overall and regional aortic SNS activities are elevated.
背景
确定胸主动脉夹层（TAD）与交感神经系统活动之间尚不明确的关系。
方法
检测并统计分析诸如心电图、血压、呼吸活动、节后肌肉交感神经活动（MSNA）、血浆去甲肾上腺素、酪氨酸羟化酶阳性神经纤维密度以及生长相关蛋白43阳性神经纤维密度等变量。
结果
与对照组相比，TAD患者的R-R间期变异性显著降低，血压、心率、呼吸频率、MSNA、血浆去甲肾上腺素（反映交感神经系统[SNS]活动增强）、酪氨酸羟化酶、生长相关蛋白43阳性神经纤维密度（反映交感神经芽生和神经支配）均更高。
结论
在TAD患者中，主动脉整体和局部的SNS活动均增强。
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