Su Naichuan, Yang Xianrui, Liu Yan, Huang Yi, Shi Zongdao
State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China; Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China; Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
J Craniomaxillofac Surg. 2014 Sep;42(6):846-51. doi: 10.1016/j.jcms.2013.12.003. Epub 2013 Dec 25.
To evaluate the changes in oral-health-related quality of life (OHRQoL) in patients with temporomandibular joint osteoarthritis (TMJ-OA) who underwent five weekly hyaluronic acid injections together with oral glucosamine hydrochloride for three months.
This prospective observational study included 211 consecutive patients who completed the Chinese version of the 14-item Oral Health Impact Profile (OHIP-C14) before treatment (T0), and at first month (T1), third month (T2), and sixth month (T3) after the first injection.
Significant changes in the summary scores on OHIP-C14 were observed during follow-up (P < 0.001). The scores were significantly reduced at T1, T2, and T3 compared with T0 (P < 0.001), and were significantly reduced from T0 to T1 (P < 0.001) and T1 to T2 (P < 0.001), but not from T2 to T3 (P = 0.369). Compared with the norms, the scores were significantly higher at T0 (P < 0.001), not significantly different at T1 (P = 0.482), and significantly lower at T2 (P = 0.013) and T3 (P = 0.003). The changes in the scores differed significantly among age groups (P = 0.012) but not between sexes (P = 0.293).
TMJ-OA has a negative effect on patient OHRQoL. OHRQoL scores were improved to normal levels in both the short and long terms after therapy. OHRQoL improvement was the greatest in the youngest group, but did not differ between the sexes.
评估颞下颌关节骨关节炎（TMJ-OA）患者接受为期五周的透明质酸注射联合口服盐酸氨基葡萄糖治疗三个月后口腔健康相关生活质量（OHRQoL）的变化。
这项前瞻性观察性研究纳入了211例连续患者，这些患者在治疗前（T0）、首次注射后第一个月（T1）、第三个月（T2）和第六个月（T3）完成了中文版14项口腔健康影响程度量表（OHIP-C14）。
随访期间OHIP-C14的总分有显著变化（P<0.001）。与T0相比，T1、T2和T3时的分数显著降低（P<0.001），且从T0到T1（P<0.001）以及从T1到T2（P<0.001）分数显著降低，但从T2到T3分数未显著降低（P=0.369）。与常模相比，T0时分数显著更高（P<0.001），T1时无显著差异（P=0.482），T2（P=0.013）和T3（P=0.003）时分数显著更低。分数变化在各年龄组间有显著差异（P=0.012），但在性别间无显著差异（P=0.293）。
TMJ-OA对患者的OHRQoL有负面影响。治疗后短期和长期OHRQoL分数均改善至正常水平。OHRQoL改善在最年轻组中最大，但在性别间无差异。
