Saria A, Martling C R, Theodorsson-Norheim E, Gamse R, Hua X Y, Lundberg J M
Department of Experimental and Clinical Pharmacology University of Graz, Austria.
Acta Physiol Hung. 1987;69(3-4):421-4.
Release of substance P (SP) and neurokinin A (NKA), was demonstrated in the isolated perfused guinea-pig lung. Significant release was obtained by perfusion with capsaicin, high potassium, histamine, bradykinin dimethylphenylpiperazinium, and by electrical vagal nerve stimulation. Capsaicin-induced peptide release was not blocked by 1 microM clonidine. SP and NKA contracted respiratory smooth muscle, NKA being 42 times more potent. Both tachykinins were equipotent in relaxing pulmonary artery. It is concluded that multiple tachykinin can be released from capsaicin-sensitive sensory nerves in the respiratory tract, exerting multiple effects on the target tissues.
在离体灌注的豚鼠肺中证实了P物质（SP）和神经激肽A（NKA）的释放。通过用辣椒素、高钾、组胺、缓激肽、二甲基苯基哌嗪灌注以及通过迷走神经电刺激可获得显著释放。1微摩尔可乐定不能阻断辣椒素诱导的肽释放。SP和NKA可使呼吸道平滑肌收缩，NKA的效力强42倍。两种速激肽在舒张肺动脉方面效力相当。结论是多种速激肽可从呼吸道中对辣椒素敏感的感觉神经释放，对靶组织发挥多种作用。
