APOBEC2 mRNA 和蛋白主要在鸡的骨骼肌和心肌中表达。
APOBEC2 mRNA and protein is predominantly expressed in skeletal and cardiac muscles of chickens.
机构信息
College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan Province 625014, China; Research Institute of Raising Livestock, Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan Province 611130, China.
College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan Province 625014, China.
出版信息
Gene. 2014 Apr 15;539(2):263-9. doi: 10.1016/j.gene.2014.01.003. Epub 2014 Jan 15.
Apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2) plays an important role in regulating and maintaining muscle development in mammals. In this study, we evaluated APOBEC2 mRNA abundance and protein expression and the results indicated that APOBEC2 mRNA was most abundant in skeletal and cardiac muscle, with relatively low expression in the gonads, gizzard and subcutaneous fat tissues of chickens. Immunoreactive APOBEC2 was localized to the cell nucleus of developing myocardium and skeletal myofibers. There were significant differences in mRNA and protein abundance among ages, tissues, and between males and females. In conclusion, APOBEC2 was expressed as the greatest in skeletal muscle and cardiac muscle where it localized to the nucleus. Thus, APOBEC2 may play an important role in muscle development in chickens.
载脂蛋白 B mRNA 编辑酶催化亚基 2（APOBEC2）在调节和维持哺乳动物肌肉发育中发挥重要作用。在这项研究中，我们评估了 APOBEC2 mRNA 的丰度和蛋白质表达，结果表明 APOBEC2 mRNA 在骨骼肌和心肌中最为丰富，在禽类的性腺、肌胃和皮下脂肪组织中表达相对较低。免疫反应性 APOBEC2 定位于发育中心肌和骨骼肌肌纤维的细胞核中。mRNA 和蛋白质丰度在不同年龄、组织和雌雄间存在显著差异。综上所述，APOBEC2 在骨骼肌和心肌中表达最为丰富，定位于细胞核。因此，APOBEC2 可能在鸡的肌肉发育中发挥重要作用。
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