对无症状性花粉症患者进行血清素鼻腔激发试验。

Nasal challenge with serotonin in asymptomatic hay fever patients.

作者信息

Tønnesen P, Schaffalitzky de Muckadell O B, Mygind N

机构信息

Dept. of Otorhinolaryngology, Rigshospitalet, Copenhagen, Denmark.

出版信息

Allergy. 1987 Aug;42(6):447-50. doi: 10.1111/j.1398-9995.1987.tb00361.x.

DOI:10.1111/j.1398-9995.1987.tb00361.x

PMID:2444128

Abstract

To study the nasal response to serotonin, 14 asymptomatic hay fever patients received intranasal serotonin in increasing doses. Itching and the number of sneezes were noted, and the amount of secretion was measured and assayed for substance P. Nasal airway resistance was recorded by active posterior rhinomanometry. Serotonin induced a dose-dependent increase in nasal itching, number of sneezes and secretion. Substance P was found in 41 of 42 secretions. The median concentration was 10.3 pmol/l (range 0-28.9), and increased parallel to increasing doses of serotonin (P less than 0.001).

摘要

为研究血清素对鼻腔的反应，14名无症状花粉热患者接受了递增剂量的鼻内血清素治疗。记录瘙痒、喷嚏次数，测量分泌物量并检测其中的P物质。通过主动后鼻测压法记录鼻气道阻力。血清素引起鼻腔瘙痒、喷嚏次数和分泌物量呈剂量依赖性增加。42份分泌物中有41份检测到P物质。中位浓度为10.3 pmol/l（范围0 - 28.9），且随血清素剂量增加而平行升高（P < 0.001）。