Kalter D C, Sperber J, Rosen T, Matarasso S
Department of Dermatology, Baylor College of Medicine, Houston.
Arch Dermatol. 1987 Oct;123(10):1315-9. doi: 10.1001/archderm.123.10.1315.
Pediculosis pubis (PP) is a common sexually transmitted disease. Current therapy with 1% lindane or various synergized pyrethrins as a single dose has been accepted as adequate by the medical community. We treated 53 men with the diagnosis of PP with either 1% lindane (Kwell) shampoo for four minutes or 1% permethrin (Nix) creme rinse for ten minutes, according to random assignment. All patients combed with fine-toothed combs immediately after therapy. They were examined for tolerance and efficacy at 24 to 48 hours and again at ten days (eight- to 12-day range). In the lindane group, ten (40%) of 25 subjects were infested at the final assessment. In the permethrin group, 12 (43%) of 28 subjects were infested at the final assessment. The difference was not statistically significant. Both treatments were well tolerated, with one mild adverse reaction in each group. We concluded that both agents were equivalent in the treatment of PP. On the basis of the high failure rate, we propose that the therapy of PP with any agent should include a second treatment at ten days.
阴虱病（PP）是一种常见的性传播疾病。目前，医学界已认可使用1%林丹或各种增效除虫菊酯单剂量治疗为充分治疗方法。我们根据随机分配原则，用1%林丹（疥得治）洗发水治疗4分钟或1%氯菊酯（虱立净）乳膏剂治疗10分钟，对53例诊断为PP的男性患者进行治疗。所有患者在治疗后立即用细齿梳子梳理。在24至48小时以及10天（8至12天范围）时对他们进行耐受性和疗效检查。在林丹组中，25名受试者中有10名（40%）在最终评估时仍有感染。在氯菊酯组中，28名受试者中有12名（43%）在最终评估时仍有感染。差异无统计学意义。两种治疗耐受性良好，每组各有1例轻度不良反应。我们得出结论，两种药物在治疗PP方面等效。基于高失败率，我们建议用任何药物治疗PP都应在10天时进行第二次治疗。
