纳洛酮对肾上腺切除大鼠毒扁豆碱诱导的升压反应的影响。

Effect of naloxone on physostigmine-induced pressor response in adrenalectomized rats.

作者信息

Oktay S, Onur R, Ilhan M, Kayaalp S O

机构信息

Department of Pharmacology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey.

出版信息

Arch Int Physiol Biochim. 1987 Jun;95(2):141-5. doi: 10.3109/13813458709104526.

DOI:10.3109/13813458709104526

PMID:2444181

Abstract

Physostigmine-induced pressor response was studied in adrenalectomized rats. The increase in mean arterial blood pressure elicited by intravenous administration of physostigmine was not altered by adrenalectomy or sham-operation. The pressor response to intracerebroventricular administration of physostigmine was found to be partially inhibited in both acutely adrenalectomized and sham-operated rats, but not in those adrenalectomized 24 h earlier. This inhibition was completely prevented by naloxone pretreatment. The results suggest that endogenous opioid peptide release induced by surgical stress may be responsible for inhibition of the pressor effect of centrally administered physostigmine in rats.

摘要

在肾上腺切除的大鼠中研究了毒扁豆碱引起的升压反应。静脉注射毒扁豆碱引起的平均动脉血压升高不受肾上腺切除术或假手术的影响。发现在急性肾上腺切除和假手术的大鼠中，脑室内注射毒扁豆碱引起的升压反应均受到部分抑制，但在24小时前肾上腺切除的大鼠中未受抑制。纳洛酮预处理可完全阻止这种抑制作用。结果表明，手术应激诱导的内源性阿片肽释放可能是大鼠中脑内注射毒扁豆碱的升压作用受到抑制的原因。