硬化性苔藓与恶性进展风险：159 例患者的病例系列。

Lichen sclerosus and the risk of malignant progression: a case series of 159 patients.

机构信息

Dermatopathological Unit San Gallicano Institute - IRCCS, Rome, Italy -

出版信息

G Ital Dermatol Venereol. 2013 Dec;148(6):673-8.

PMID:24442050

Abstract

AIM AND METHODS

We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous-hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed.

RESULTS AND CONCLUSION

The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

摘要

目的与方法

我们分析了 1999 年至 2011 年间收集的 159 例硬化性苔藓（LS）的 159 份储存标本，以评估组织学模式、临床结果和与恶性肿瘤的可能关联。组织病理学分析显示 145 例（男性和女性）单纯 LS，7 例阴茎 LS 与鳞状细胞癌（SCC）相关，7 例 LS 与假癌性增生（PCH）相关。在 20%（17/85）的男性和 78%（58/74）的女性中发现外生殖器 LS。在 SCC 病例中进行了免疫组织化学分析。