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[心房颤动的控制及其发生的可能机制]

[Controlled atrial fibrillation and a possible mechanism of its genesis].

作者信息

Sheĭkh-Zade Iu R, Galenko-Iaroshevskiĭ P A

出版信息

Biull Eksp Biol Med. 1987 Sep;104(9):261-3.

PMID:2444284
Abstract

In experiments on cats a single premature beat or vagal stimulation shortened the effective refractory period without any spontaneous heart rate disturbances, while the combined action of these factors always led to paroxysmal tachycardia or atrial fibrillation. It is suggested that contracting myocardium possesses a covert ability for self-excitation revealed only in critical shortening of the action potential. Since the excitation occurring in such conditions is also a premature beat, the fibrillation process becomes self-maintaining.

摘要

在对猫的实验中,单个早搏或迷走神经刺激可缩短有效不应期,且无任何自发性心率紊乱,而这些因素的联合作用总是导致阵发性心动过速或心房颤动。有人提出,收缩期心肌具有一种仅在动作电位严重缩短时才显现的潜在自激能力。由于在这种情况下发生的兴奋也是早搏,因此纤颤过程会自我维持。

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