类风湿关节炎中痛风的发生：确实会出现！一项基于人群的研究。
Occurrence of gout in rheumatoid arthritis: it does happen! A population-based study.
作者信息
Jebakumar Adlene J, Udayakumar Prabhu D, Crowson Cynthia S, Matteson Eric L
机构信息
Division of Rheumatology, Department of Medicine, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Division of Rheumatology, Department of Medicine, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA ; Division of Biomedical Statistics & Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
出版信息
Int J Clin Rheumtol. 2013 Aug;8(4):433-437. doi: 10.2217/ijr.13.45.
AIM
It has been a popular belief that gout does not typically occur in patients with rheumatoid arthritis (RA). Our aim was to assess the occurrence, prevalence, clinical presentation and possible risk factors for gout in patients with RA.
PATIENTS & METHODS: We retrospectively reviewed a population-based incidence cohort of patients who fulfilled 1987 ACR criteria for RA between 1980 and 2007. The cumulative prevalence of gout in RA adjusted for the competing risk of death was estimated.
RESULTS
Among the 813 patients with RA, six were diagnosed with gout prior to RA incidence and 22 patients developed gout during a total of 9771 person-years of follow-up. Nine out of 22 patients had crystal-proven gout. The 25-year cumulative prevalence of gout diagnosed by clinical criteria in patients with RA was 5.3%.
CONCLUSION
Gout does occur in patients with rheumatoid arthritis, however, at a lower rate than in the general population.
目的
人们普遍认为类风湿关节炎（RA）患者一般不会发生痛风。我们的目的是评估RA患者中痛风的发生率、患病率、临床表现及可能的危险因素。
患者与方法
我们回顾性分析了1980年至2007年间符合1987年美国风湿病学会（ACR）RA标准的人群发病率队列。估算了针对死亡竞争风险进行调整后的RA患者痛风累积患病率。
结果
在813例RA患者中，6例在RA发病前被诊断为痛风，22例在总共9771人年的随访期间发生痛风。22例患者中有9例经晶体证实为痛风。根据临床标准诊断的RA患者痛风25年累积患病率为5.3%。
结论
类风湿关节炎患者确实会发生痛风，然而，其发生率低于普通人群。
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