合成微型脂阿拉伯甘露聚糖。
Synthesis of a miniature lipoarabinomannan.
机构信息
Department of Chemistry, Wayne State University , Detroit, Michigan 48202, United States.
出版信息
Org Lett. 2014 Feb 7;16(3):988-91. doi: 10.1021/ol4036903. Epub 2014 Jan 21.
Abstract
An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.
摘要
已经合成了结核分枝杆菌脂阿拉伯甘露聚糖（LAM）的类似物，其中包含其三个主要成分的所有特征结构; 即，甘露糖基化磷脂酰肌醇部分，寡甘露聚糖和寡阿拉伯聚糖。开发了一种高度会聚的策略，该策略适用于其他 LAM 类似物的合成。这种合成的微型 LAM 应该对各种生物学研究有用。
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