Kemkes-Matthes B, Preissner K T, Langenscheidt F, Matthes K J, Müller-Berghaus G
Department of Internal Medicine, Justus-Liebig-Universität, Giessen, Germany.
Eur J Haematol. 1987 Aug;39(2):161-5. doi: 10.1111/j.1600-0609.1987.tb00747.x.
S protein/vitronectin plays an important role as a regulatory component in the terminal steps of the complement- and coagulation cascades. In patients suffering from chronic liver diseases, plasma S protein concentration was measured and compared with changes in serum cholinesterase activity, coagulation factor X activity and complement component C3 concentration. Significant decreases of all these proteins were seen in liver cirrhosis. Changes in S protein concentration correlated closely with those of cholinesterase, factor X and complement C3. The data give support for the liver as the main organ of plasma S protein/vitronectin synthesis.
S蛋白/玻连蛋白作为补体和凝血级联反应终末步骤中的一种调节成分发挥着重要作用。对慢性肝病患者测定血浆S蛋白浓度，并与血清胆碱酯酶活性、凝血因子X活性及补体成分C3浓度的变化进行比较。在肝硬化患者中可见所有这些蛋白质均显著降低。S蛋白浓度的变化与胆碱酯酶、因子X和补体C3的变化密切相关。这些数据支持肝脏是血浆S蛋白/玻连蛋白合成的主要器官。
