万古霉素在儿科肿瘤患者中的剂量临床评估。
Clinical evaluation of vancomycin dosage in pediatric oncology patients.
机构信息
From the *Department of Clinical Pharmacy; †Department of Pediatric Infectious Diseases; and ‡Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Pediatr Infect Dis J. 2014 Jul;33(7):731-3. doi: 10.1097/INF.0000000000000268.
Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.
万古霉素谷浓度在接受 60mg/kg/d 分 4 次给药的 124 例儿科肿瘤患者中，有 58%低于治疗范围（8-15mg/L）。<6 岁和 6-12 岁的患者比>12 岁的患者谷浓度明显更低。对于>12 岁的儿科肿瘤患者，60mg/kg/d 的万古霉素剂量不足。
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