单核细胞衍生的组胺释放增强因子的特性分析
Characterization of mononuclear cell-derived histamine release enhancing factor.
作者信息
Younger R E, Herrod H G, Lieberman P L, Valenski W R, Trouy R L, Crawford L V
机构信息
Department of Pediatrics, University of Tennessee Center for the Health Sciences, Chattanooga 37403.
出版信息
J Allergy Clin Immunol. 1987 Oct;80(4):547-57. doi: 10.1016/0091-6749(87)90006-6.
Histamine release enhancing factor (HREF) is a product of phytohemagglutinin-stimulated mononuclear cells that substantially augments in vitro IgE-mediated basophil histamine release. The factor is stable at 56 degrees C and has a molecular weight in the 10,000 to 30,000 dalton range. The magnitude of HREF activity produced is dependent on the concentration of mononuclear cells cultured and the final concentration of HREF during basophil challenge. The HREF phenomenon could not be attributed to phytohemagglutinin, alpha- or gamma-interferon, arachidonic acid metabolites, or interleukin-1 or 2. HREF appears to be a unique cytokine of potential importance in the immunology of inflammatory and atopic processes.
组胺释放增强因子（HREF）是植物血凝素刺激的单核细胞的产物，它能显著增强体外IgE介导的嗜碱性粒细胞组胺释放。该因子在56摄氏度时稳定，分子量在10,000至30,000道尔顿范围内。产生的HREF活性大小取决于培养的单核细胞浓度以及嗜碱性粒细胞激发过程中HREF的终浓度。HREF现象不能归因于植物血凝素、α或γ干扰素、花生四烯酸代谢产物或白细胞介素-1或2。HREF似乎是一种在炎症和特应性过程免疫学中具有潜在重要性的独特细胞因子。
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