Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.
Dermatol Surg. 2014 Apr;40(4):460-7. doi: 10.1111/dsu.12446. Epub 2014 Jan 21.
Planning reconstruction for facial defects should include the safest and least-invasive methods, with a goal of achieving optimal functional and cosmetic outcomes.
To compare tissue-engineered dermis grafts with artificial dermis grafts after removal of basal cell carcinoma (BCC) on the face.
A tissue-engineered dermis composed of autologous cultured dermal fibroblasts seeded on a hyaluronic acid sheet was applied to 16 patients. Grafting of hyaluronic acid sheets that did not contain fibroblasts (artificial dermis group) was performed in 13 patients. Healing time, scar condition, and patient satisfaction were compared.
The wounds of the tissue-engineered dermis group reepithelialized after 31.4 ± 5.3 days and those of the artificial dermis group after 34.2 ± 4.9 days. The tissue-engineered dermis graft was superior in scar quality. In particular, statistically significant differences were detected in the height and contracture of scars, although there were no significant differences in terms of scar texture or color match. Patient satisfaction in the tissue-engineered dermis graft group (8.3 ± 1.0) was also statistically superior to that in the artificial dermis group (6.9 ± 1.4).
The tissue-engineered dermis graft is superior to the artificial dermis graft for covering defects after removal of BCC on the face.
面部缺损的重建规划应包括最安全和微创的方法，以实现最佳的功能和美容效果。
比较面部基底细胞癌（BCC）切除后组织工程真皮移植物与人工真皮移植物的效果。
将自体培养的成纤维细胞接种在透明质酸片上制成的组织工程真皮应用于 16 例患者。13 例患者行未含成纤维细胞的透明质酸片移植（人工真皮组）。比较愈合时间、瘢痕情况和患者满意度。
组织工程真皮组的创面在 31.4±5.3 天内再上皮化，而人工真皮组在 34.2±4.9 天内再上皮化。组织工程真皮移植物的瘢痕质量更好。特别是在瘢痕高度和挛缩方面，差异有统计学意义，尽管在瘢痕质地或颜色匹配方面无显著差异。组织工程真皮移植物组（8.3±1.0）的患者满意度也明显优于人工真皮组（6.9±1.4）。
组织工程真皮移植物在面部 BCC 切除后覆盖缺损方面优于人工真皮移植物。
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