Althof S E, Turner L A, Levine S B, Risen C, Kursh E D, Bodner D, Resnick M
Case Western Reserve University School of Medicine, Cleveland, OH.
J Sex Marital Ther. 1987 Fall;13(3):155-67. doi: 10.1080/00926238708403889.
This study assessed the sexual, psychosocial, and medical impact of intracavernosal injection of papaverine hydrochloride and phentolamine mesylate in the treatment of impotence. Ninety-six percent of patients initially achieved satisfactory erections with injections. Common side effects of self-injections included bruising (26%), nodule development (21%), abnormal liver function tests (7%), and pain (5%). No nodules resulted in penile bending or pain, and no patient discontinued treatment due to nodule development. Dropout rate to date was 35%. Self-injection treatment was associated with increases in erection quality, intercourse frequency, and sexual satisfaction, and decreases in masturbation frequency for patients. Partners also reported increases in intercourse frequency, coital arousal, and satisfaction. Decreases in general psychiatric symptomatology and increases in relationship satisfaction and self-esteem were apparent for patients, but not for partners.
本研究评估了海绵体内注射盐酸罂粟碱和甲磺酸酚妥拉明治疗阳痿的性、心理社会及医学影响。96%的患者最初通过注射获得了满意的勃起。自我注射的常见副作用包括瘀伤（26%）、结节形成（21%）、肝功能检查异常（7%）和疼痛（5%）。没有结节导致阴茎弯曲或疼痛，也没有患者因结节形成而停止治疗。迄今为止的脱落率为35%。自我注射治疗与患者勃起质量、性交频率和性满意度的提高以及手淫频率的降低有关。伴侣也报告性交频率、性交唤起和满意度有所增加。患者的一般精神症状有所减轻，关系满意度和自尊有所提高，但伴侣没有。
