睾丸癌中碱性甲胎蛋白的临床评估
Clinical evaluation of basic fetoprotein in testicular cancer.
作者信息
Harada K, Morishita S, Itani A, Nagata H, Hamami G, Ishii M, Kamidono S, Ishigami J
机构信息
Department of Urology, Kobe University School of Medicine, Japan.
出版信息
J Urol. 1987 Nov;138(5):1178-80. doi: 10.1016/s0022-5347(17)43542-7.
We attempted to determine the efficacy of basic fetoprotein as a marker in testicular cancer. The levels of serum basic fetoprotein were studied in 58 patients (31 with seminoma and 27 with nonseminoma). Elevated levels were observed in 22 seminoma (71 per cent) and 15 nonseminoma (56 per cent) patients, while the levels of other markers (beta-subunit of human chorionic gonadotropin, alpha-fetoprotein and lactic dehydrogenase) remained normal in 6 seminoma (19 per cent) and 2 nonseminoma (7 per cent) patients. The levels of basic fetoprotein changed in relation to the clinical courses and they elevated again in 3 of 4 patients with recurrence. The concentration of basic fetoprotein in testicular cancer tissue was significantly higher than in the normal testis. Histological localization of basic fetoprotein in testicular cancer tissue was demonstrated immunohistochemically. Thus, basic fetoprotein was considered to be a useful serum marker for testicular cancer.
我们试图确定碱性甲胎蛋白作为睾丸癌标志物的有效性。对58例患者（31例精原细胞瘤患者和27例非精原细胞瘤患者）的血清碱性甲胎蛋白水平进行了研究。22例精原细胞瘤患者（71%）和15例非精原细胞瘤患者（56%）观察到碱性甲胎蛋白水平升高，而6例精原细胞瘤患者（19%）和2例非精原细胞瘤患者（7%）的其他标志物（人绒毛膜促性腺激素β亚基、甲胎蛋白和乳酸脱氢酶）水平保持正常。碱性甲胎蛋白水平随临床病程变化，4例复发患者中有3例碱性甲胎蛋白水平再次升高。睾丸癌组织中碱性甲胎蛋白的浓度显著高于正常睾丸。通过免疫组织化学方法证实了碱性甲胎蛋白在睾丸癌组织中的组织学定位。因此，碱性甲胎蛋白被认为是睾丸癌的一种有用的血清标志物。
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