Zhang Yu, Ma Li-wen
Department of Oncology and Radiation Sickness, Cancer Center, Peking University Third Hospital, Beijing 100191, China.
Department of Oncology and Radiation Sickness, Cancer Center, Peking University Third Hospital, Beijing 100191, China. Email:
Zhonghua Zhong Liu Za Zhi. 2013 Nov;35(11):863-6.
To analyze the results of long-term follow up of patients with postoperative stage III gastric cancer and the prognostic factors.
We retrospectively analyzed the clinicopathological data of 114 patients with stage III gastric cancer treated in our hospital from April 1998 to January 2006. Kaplan-Meier univariate analysis and Cox regression analysis were performed to evaluate the candidate prognostic factors, such as gender, age, pathological stage, histological differentiation, lymphovascular tumor thrombus, tumor residual and postoperative chemotherapy.
In the 114 cases, the 5-year overall survival rate was 28.6% and 10-year survival rate was 22.6%. The 5-year survival rates of stage IIIA, IIIB and IIIC patients were 38.3%, 33.8% and 19.5%, respectively, and 10-year survival rates were 33.5%, 29.6% and 11.1%, respectively. Univariate analysis showed that pathological stage, tumor residual and postoperative chemotherapy were significantly correlated with prognosis (P < 0.05). Multivariate analysis showed that pathological stage, tumor residual and postoperative chemotherapy were independent prognostic factors of stage III gastric cancer patients (P < 0.05 for all).
The long-term survival of stage III gastric cancer patients remains poor. Pathological stage, tumor residual and postoperative chemotherapy are the most significant factors influencing prognosis of stage III gastric cancer after radical resection. Postoperative chemotherapy can improve their survival.
分析Ⅲ期胃癌患者术后长期随访结果及预后因素。
回顾性分析1998年4月至2006年1月在我院接受治疗的114例Ⅲ期胃癌患者的临床病理资料。采用Kaplan-Meier单因素分析和Cox回归分析评估性别、年龄、病理分期、组织学分化、淋巴管瘤栓、肿瘤残留及术后化疗等候选预后因素。
114例患者中，5年总生存率为28.6%，10年生存率为22.6%。ⅢA期、ⅢB期和ⅡIC期患者的5年生存率分别为38.3%、33.8%和19.5%，10年生存率分别为33.5%、29.6%和11.1%。单因素分析显示，病理分期、肿瘤残留及术后化疗与预后显著相关（P<0.05）。多因素分析显示，病理分期、肿瘤残留及术后化疗是Ⅲ期胃癌患者的独立预后因素（均P<0.05）。
Ⅲ期胃癌患者的长期生存率仍然较低。病理分期、肿瘤残留及术后化疗是影响Ⅲ期胃癌根治术后预后的最重要因素。术后化疗可提高其生存率。
