Liang Jiancong, Libien Jenny, Kunam Vamsi, Shao Charles, Rao Chandrakant
Clin Neuropathol. 2014 May-Jun;33(3):197-202. doi: 10.5414/NP300702.
Ectopic pituitary adenomas are uncommon entities that may pose substantial diagnostic challenges. In the majority of these cases, patients present with endocrine and/or nasal obstruction symptoms. We report the case of an ectopic pituitary adenoma in a 76-year-old man with an empty sella who initially presented with right-sided hearing loss progressing to bilateral hearing loss over the next 4 years. Neuroimaging studies revealed a large, expansile central skull base mass replacing the clivus and sphenoid sinus, and invading the internal auditory canals and inner ear bilaterally. The tumor also involved the floor of the middle cranial fossae and bilateral medial temporal and occipital bones. Histopathologic examination, including immunohistochemical studies, revealed a sparsely granulated lactotroph adenoma. Hearing loss in a patient with ectopic pituitary adenoma constitutes an extremely unusual presentation. This case was further complicated by the presence of an empty sella and the absence of symptoms related to hyperprolactinemia.
异位垂体腺瘤是一种罕见的疾病，可能带来重大的诊断挑战。在大多数此类病例中，患者表现出内分泌和/或鼻塞症状。我们报告一例76岁患有空蝶鞍的男性异位垂体腺瘤病例，该患者最初表现为右侧听力丧失，在接下来的4年中进展为双侧听力丧失。神经影像学研究显示，一个巨大的、膨胀性的中央颅底肿块取代了斜坡和蝶窦，并双侧侵犯内耳道和内耳。肿瘤还累及中颅窝底以及双侧颞内侧和枕骨。组织病理学检查，包括免疫组化研究，显示为稀疏颗粒型催乳素细胞腺瘤。异位垂体腺瘤患者出现听力丧失是一种极其罕见的表现。该病例因存在空蝶鞍且无高催乳素血症相关症状而更加复杂。
