DAOA基因多态性与精神分裂症、双相情感障碍和抑郁症风险之间的关联。

Association between DAOA gene polymorphisms and the risk of schizophrenia, bipolar disorder and depressive disorder.

作者信息

Tan Jinjing, Lin Yu, Su Li, Yan Yan, Chen Qing, Jiang Haiyun, Wei Qiugui, Gu Lian

机构信息

Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, 89-9 Dongge Road, Nanning, Guangxi, China.

School of Preclinical Medicine of Guangxi Medical University, Nanning, Guangxi, China.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:89-98. doi: 10.1016/j.pnpbp.2014.01.007. Epub 2014 Jan 19.

DOI:10.1016/j.pnpbp.2014.01.007

PMID:24447945

Abstract

OBJECTIVE

Schizophrenia (SCZ), bipolar disorder (BD) and depressive disorder (DD) are common psychiatric disorders, which show common genetic vulnerability. Previous gene-disease association studies have reported correlations between d-amino acid oxidase activator (DAOA) gene polymorphisms and the three psychiatric disorders. However, the findings were contradictory. A meta-analysis was therefore conducted to provide more robust investigations into DAOA polymorphisms and the risk of SCZ, BD and DD.

METHODS

This meta-analysis recruited 46 published studies up to July 2013, including 17,515 cases and 25,189 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between three specific DAOA SNPs and SCZ, BD and DD. Publication bias was tested by Begg's test and funnel plot, and heterogeneity was assessed by the Cochran's chi-square-based Q statistic and the inconsistency index (I(2)). Moreover, the robustness of the findings was estimated by cumulative meta-analysis.

RESULTS

DAOA genetic polymorphisms (M15, M18 and M23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.

CONCLUSION

The current study indicated that M15, M18 and M23 might not be the risk factor for SCZ, BD or DD. However, further studies are required to provide robust evidence to estimate the association between DAOA polymorphisms and psychiatric disorders.

摘要

目的

精神分裂症（SCZ）、双相情感障碍（BD）和抑郁症（DD）是常见的精神疾病，它们表现出共同的遗传易感性。先前的基因与疾病关联研究报道了d-氨基酸氧化酶激活剂（DAOA）基因多态性与这三种精神疾病之间的相关性。然而，研究结果相互矛盾。因此，进行了一项荟萃分析，以更有力地研究DAOA多态性与SCZ、BD和DD风险之间的关系。

方法

该荟萃分析纳入了截至2013年7月发表的46项研究，包括17515例病例和25189例对照。采用比值比（OR）及其95%置信区间（CI）来评估三种特定的DAOA单核苷酸多态性（SNP）与SCZ、BD和DD之间的关联。通过Begg检验和漏斗图检验发表偏倚，并采用基于Cochran卡方的Q统计量和不一致指数（I²）评估异质性。此外，通过累积荟萃分析评估研究结果的稳健性。