Division of Cardiovascular Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO.
Rev Cardiovasc Med. 2013;14(2-4):e82-91. doi: 10.3909/ricm0620.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting more than 2.6 million people in the United States. It occurs frequently after myocardial infarction and is the most common arrhythmia following cardiac surgery. AF increases the risk of morbidity and mortality from stroke, thromboembolism, and death. AF may be caused by ectopic activity in one or more of the pulmonary veins. Focal ectopic activity can be generated by abnormal atrial automaticity, delayed afterdepolarizations from calcium overload, or early afterdepolarizations secondary to defective repolarization properties. Pathologic mechanisms may include autonomic dysfunction, inflammation, and fibrosis. Omega-3 fatty acids (polyunsaturated fatty acids [PUFAs]) have been shown to induce beneficial effects in the treatment of coronary artery disease. They may also reduce sudden cardiac death and the incidence of arrhythmias. Therefore, studies have been conducted to evaluate the benefits of PUFAs in arrhythmia prevention. This review describes the effects of PUFAs in AF and provides the current literature in the prevention of AF.
心房颤动（AF）是最常见的心律失常，影响超过 260 万美国人。它在心肌梗死后经常发生，是心脏手术后最常见的心律失常。AF 增加了中风、血栓栓塞和死亡的发病率和死亡率。AF 可能由一个或多个肺静脉中的异位活动引起。局灶性异位活动可由异常的心房自律性、钙超载引起的延迟后除极或由于复极化特性缺陷引起的早期后除极产生。病理机制可能包括自主神经功能障碍、炎症和纤维化。已经表明ω-3 脂肪酸（多不饱和脂肪酸[PUFAs]）在治疗冠状动脉疾病方面具有有益的作用。它们还可能减少心脏性猝死和心律失常的发生率。因此，已经进行了研究以评估 PUFAs 在预防心律失常中的益处。这篇综述描述了 PUFAs 在 AF 中的作用，并提供了预防 AF 的当前文献。
