Singh R B
Medical Hospital and Research Center, Moradabad, India.
Med Hypotheses. 1987 Sep;24(1):1-9. doi: 10.1016/0306-9877(87)90041-7.
Mg and verapamil have similar effects on the cardiovascular system. Both the agents have been successfully used for the treatment of hypertension and protection of the ischaemic myocardium. The exact mechanism of action of calcium blocking drugs including verapamil is unknown. It is proposed that verapamil stimulates the Mg-carrying transport system and Mg diffusion in the cell so that Mg influx is enhanced. This in turn causes suppression of the slow inward Ca current and fast inward Na current resulting into decreased transport of Ca and Na. Verapamil possibly also influences outward K and Mg currents and alter the shape and duration of the action potential. Since Mg ions maintain the structural and functional integrity of the cardiovascular system, therefore Mg mediated mechanisms of action for verapamil appears to be more logical.
镁和维拉帕米对心血管系统有相似作用。这两种药物均已成功用于治疗高血压和保护缺血心肌。包括维拉帕米在内的钙通道阻滞剂的确切作用机制尚不清楚。有人提出，维拉帕米可刺激细胞内携带镁的转运系统和镁的扩散，从而增强镁的内流。这进而导致慢内向钙电流和快内向钠电流受到抑制，从而减少钙和钠的转运。维拉帕米可能还会影响外向钾电流和镁电流，并改变动作电位的形状和持续时间。由于镁离子维持心血管系统的结构和功能完整性，因此镁介导的维拉帕米作用机制似乎更合理。
