Townsend Mary K, Minassian Vatché A, Okereke Olivia I, Resnick Neil M, Grodstein Francine
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA,
Int Urogynecol J. 2014 Jun;25(6):823-9. doi: 10.1007/s00192-013-2309-2. Epub 2014 Jan 22.
Previous studies report higher prevalence of depression among women with urgency (UUI) or mixed (MUI) urinary incontinence than those with stress UI (SUI). UUI is the dominant type among black women, whereas SUI is the predominant type among white women. Thus, UI-related mental health issues could be a key consideration among black women. We hypothesized that the association between UI and depression might be stronger in black versus white women.
These cross-sectional analyses assessed 934 black and 71,161 white women aged 58-83 in the Nurses' Health Study, which was established among women living in the USA. Depressive symptoms were assessed using the ten-item Center for Epidemiologic Studies Depression Scale (CESD-10). Multivariate adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for high depressive symptoms (CESD-10 score ≥ 10) according to self-reported UI frequency, severity, and type were calculated using logistic regression models.
Although point estimates for associations of UI frequency, severity, and type with high depressive symptoms were higher in black women, differences in ORs between black versus white women were not statistically significant. For example, the OR for at least weekly UI compared with no UI was 2.29 (95 % CI 1.30-4.01) in black women and 1.58 (95 % CI 1.49-1.68) in white women (p interaction = 0.4).
We found no statistically significant differences in UI frequency, severity, and type with high depressive symptoms in black versus white women. However, the small number of black women in this study with high depressive symptoms limited statistical power to detect significant interactions. Thus, these results should be interpreted with caution.
既往研究报告称,患有急迫性尿失禁(UUI)或混合性尿失禁(MUI)的女性比患有压力性尿失禁(SUI)的女性抑郁症患病率更高。UUI是黑人女性中占主导的类型,而SUI是白人女性中最主要的类型。因此,与尿失禁相关的心理健康问题可能是黑人女性的一个关键考量因素。我们假设,尿失禁与抑郁症之间的关联在黑人女性中可能比白人女性更强。
这些横断面分析评估了美国护士健康研究中934名年龄在58 - 83岁的黑人女性和71161名白人女性。使用十项流行病学研究中心抑郁量表(CESD - 10)评估抑郁症状。根据自我报告的尿失禁频率、严重程度和类型,使用逻辑回归模型计算高抑郁症状(CESD - 10得分≥10)的多变量调整比值比(OR)和95%置信区间(CI)。
尽管黑人女性中尿失禁频率、严重程度和类型与高抑郁症状之间关联的点估计值更高,但黑人女性与白人女性之间的OR差异无统计学意义。例如,与无尿失禁相比,至少每周发生一次尿失禁的黑人女性的OR为2.29(95%CI 1.30 - 4.01),白人女性为1.58(95%CI 1.49 - 1.68)(p交互作用 = 0.4)。
我们发现黑人女性与白人女性在尿失禁频率、严重程度和类型与高抑郁症状方面无统计学显著差异。然而,本研究中患有高抑郁症状的黑人女性数量较少,限制了检测显著交互作用的统计效力。因此,对这些结果的解释应谨慎。