Demel Anja, Feilke Katharina, Wolf Martin, Poets Christian F, Franz Axel R
University Children's Hospital Tuebingen, Department of Neonatology, Calwerstr. 7, 72076 Tuebingen, Germany.
University Hospital Zurich, Biomedical Optics Research Laboratory, Division of Neonatology, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
J Biomed Opt. 2014 Jan;19(1):17004. doi: 10.1117/1.JBO.19.1.017004.
Near-infrared spectroscopy (NIRS) is increasingly used in neonatal intensive care. We investigated the impact of skin, bone, and cerebrospinal fluid (CSF) layer thickness in term and preterm infants on absorption-(μa) and/or reduced scattering coefficients (μs') measured by multidistance frequency-domain (FD)-NIRS. Transcranial ultrasound was performed to measure the layer thicknesses. Correlations were only statistically significant for μa at 692 nm with bone thickness and μs' at 834 nm with skin thickness. There is no evidence that skin, bone, or CSF thickness have an important effect on μa and μs'. Layer thicknesses of skin, bone, and CSF in the range studied do not seem to affect cerebral oxygenation measurements by multidistance FD-NIRS significantly.
近红外光谱技术（NIRS）在新生儿重症监护中的应用越来越广泛。我们研究了足月儿和早产儿的皮肤、骨骼及脑脊液（CSF）层厚度对多距离频域（FD）-NIRS测量的吸收系数（μa）和/或约化散射系数（μs'）的影响。采用经颅超声测量层厚度。仅在692 nm处的μa与骨厚度以及834 nm处的μs'与皮肤厚度之间的相关性具有统计学意义。没有证据表明皮肤、骨骼或脑脊液厚度对μa和μs'有重要影响。在所研究范围内，皮肤、骨骼和脑脊液的层厚度似乎不会显著影响多距离FD-NIRS对脑氧合的测量。
