Vorontsova Yu E, Cherezov R O, Simonova O B
Genetika. 2013 Jun;49(6):669-80. doi: 10.7868/s0016675813050135.
In Drosophila, one of the genes of the lawc/Trf2 (leg-arista-wing complex/TBP-related factor 2) complex encodes an alternative basic transcription factor homologous to the TRF2 protein in vertebrates and human and belongs to a conservative Tbp (TATA box-binding protein) gene family. In the present study, reasons for the high frequency of chromosome nondisjunction were studied among descendants of mutants from 18 lines with a decreased expression of the TRF2 protein. It was determined that the suppression of the TRF2 expression violates the development of a compact chromocenter and the correct approach of homologous chromosomes (in germinative and somatic cells). The possibility of the participation of TRF2 in the evolutionary genetically programmed process of sex-ratio violation, which is typical of a number of animal species, is discussed.
在果蝇中，lawc/Trf2（腿-触角-翅复合体/TBP相关因子2）复合体的一个基因编码一种与脊椎动物和人类中的TRF2蛋白同源的替代性基本转录因子，属于保守的Tbp（TATA盒结合蛋白）基因家族。在本研究中，对18个TRF2蛋白表达降低品系的突变体后代中染色体不分离高频出现的原因进行了研究。已确定TRF2表达的抑制会破坏紧密染色中心的发育以及同源染色体（在生殖细胞和体细胞中）的正确配对。还讨论了TRF2参与许多动物物种所特有的违反性别比例的进化遗传编程过程的可能性。
