Li Li, Ma Yi, Geng Xue-Bin, Song Yu-Xin, Tan Zheng, Shang Xiao-Ming, Zhao Guo-Yu, Zhao Bi-Qiong, Tian Mei-Rong
Department of Cardiovascular Medicine, The Tangshan Affiliated Clinical Hospital of Hebei Medical University, Tangshan, Hebei, P.R. China.
Am J Ther. 2016 Jan-Feb;23(1):e318-20. doi: 10.1097/MJT.0000000000000012.
Although statins are generally well-tolerated drugs, recent cases of drug-induced liver injury associated with their use have been reported. A 52-year-old Chinese man reported with liver damage, which appeared 12 hours after beginning treatment with fluvastatin. Patient presented with complaints of increasing nausea, anorexia, and upper abdominal pain. His laboratory values showed elevated creatine kinase and transaminases. Testing for autoantibodies was also negative. The liver biochemistries eventually normalized within 3 weeks of stopping the fluvastatin. Therefore, when prescribing statins, the possibility of hepatic damage should be taken into account.
尽管他汀类药物通常是耐受性良好的药物，但最近已有与其使用相关的药物性肝损伤病例报道。一名52岁的中国男性在开始使用氟伐他汀治疗12小时后出现肝损伤。患者主诉恶心、厌食和上腹部疼痛加重。他的实验室检查值显示肌酸激酶和转氨酶升高。自身抗体检测也为阴性。在停用氟伐他汀3周内，肝脏生化指标最终恢复正常。因此，在开具他汀类药物处方时，应考虑肝损伤的可能性。
