[儿童B群脑膜炎球菌感染中对荚膜多糖抗原的抗体反应]

[Antibody response to capsular polysaccharide antigen in an infection caused by meningococcus serogroup B in children].

作者信息

Kostiukova N N, Basnak'ian I A, Aleksakhina N N, Borovkova V M, Derkach S A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1987 Jul(7):49-53.

Abstract

The continuous synchronous cultivation of serogroup B meningococci and the use of the selected clones of producer strains has made it possible to obtain the serologically active preparation of the group-specific antigen from the culture in the exponential phase. The erythrocyte diagnosticum produced on the basis of this preparation has permitted the detection of group-specific antibodies in the sera of immunized rabbits and children with generalized infection caused by serogroup B meningococci. The intensity of immune response depends on the age of children. This new technique of the passive hemagglutination test is recommended for the confirmation of generalized infection caused by serogroup B meningococci.

摘要

对B群脑膜炎球菌进行连续同步培养，并使用选定的生产菌株克隆，使得从指数生长期的培养物中获得具有血清学活性的群特异性抗原制剂成为可能。基于该制剂生产的红细胞诊断试剂已能够检测免疫兔血清以及由B群脑膜炎球菌引起的全身感染患儿血清中的群特异性抗体。免疫反应的强度取决于儿童的年龄。推荐使用这种新型被动血凝试验技术来确诊由B群脑膜炎球菌引起的全身感染。