5-氮杂胞苷诱导的失活X染色体基因重新激活与复制模式的改变无关。
Inactive X chromosome gene reactivation induced by 5-azacytidine, is not correlated with the modification of the pattern of replication.
作者信息
Hors-Cayla M C, Couturier J, Homman N, Heuertz S, Frézal J
机构信息
Unité de Recherches de Génétique Médicale INSERM U12, Hôpital des Enfants Malades, Paris.
出版信息
Ann Genet. 1987;30(3):153-7.
PMID:2445256
Abstract
The replication pattern of a human inactive X chromosome reactivated for one to four genes by 5-azacytidine has been studied by the BrdU-33258-Hoechst-Giemsa technique in four subclones of a somatic hamster-human hybrid. In one of them the pattern was clearly modified. In the three others the changes were not significant. No correlation was found between expression and replication.
摘要
利用BrdU-33258- Hoechst-吉姆萨技术，在一个体细胞仓鼠-人杂交体的四个亚克隆中，研究了通过5-氮杂胞苷重新激活一至四个基因的人类失活X染色体的复制模式。其中一个亚克隆的模式有明显改变。另外三个亚克隆中的变化不显著。未发现表达与复制之间存在相关性。
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