Cervantes-Vega C, Chávez J
Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana, Morelia, México.
Antonie Van Leeuwenhoek. 1987;53(4):253-9. doi: 10.1007/BF00393932.
Susceptibility to inorganic mercuric ions and to organomercurials of 237 Pseudomonas aeruginosa clinical strains isolated in Mexico was determined by agar dilution tests. Resistant strains fell into two classes: i) narrow-spectrum resistant strains (27% of total isolates) resistant only to mercuric ions and to merbromin, and most grouped in pyocin type 1; and ii) broad-spectrum resistant strains (5%) with additional resistances to thimerosal, phenylmercury, methylmercury and p-hydroxymercuribenzoate, that belonged mostly to pyocin type 10. Mercurial resistant isolates showed a higher proportion of resistance to antibiotics and metals than did mercurial sensitive isolates, and broad-spectrum resistant strains had the highest frequency of resistance to antibiotics and to tellurite and arsenate.
通过琼脂稀释试验测定了在墨西哥分离出的237株铜绿假单胞菌临床菌株对无机汞离子和有机汞化合物的敏感性。耐药菌株分为两类：i）窄谱耐药菌株（占分离菌株总数的27%），仅对汞离子和汞溴红耐药，且大多数属于1型绿脓菌素；ii）广谱耐药菌株（5%），对硫柳汞、苯基汞、甲基汞和对羟基汞苯甲酸盐也有额外耐药性，大多属于10型绿脓菌素。汞耐药分离株比对汞敏感的分离株表现出更高比例的抗生素和金属耐药性，而广谱耐药菌株对抗生素、亚碲酸盐和砷酸盐的耐药频率最高。
