异烟肼诱发的小脑炎：一种隐匿的表现形式。
Isoniazid-induced cerebellitis: a disguised presentation.
作者信息
Peter Prasant, John Mary
机构信息
Department of Radiodiagnosis, Christian Medical College and Hospital, Ludhiana, Punjab, Pin-141008, India.
出版信息
Singapore Med J. 2014 Jan;55(1):e17-9. doi: 10.11622/smedj.2013188.
Abstract
Cerebellitis is a rarely encountered complication of isoniazid therapy. Its occurrence is usually associated with concomitant renal disease and haemodialysis. Herein, we report the case of a patient with this complication who presented with isolated bilateral symmetrical dentate nucleus T2 hyperintensities on magnetic resonance imaging. Isoniazid neurotoxicity has never been reported to cause bilateral dentate hyperintensities, for which the differentials are few and include metronidazole toxicity.
摘要
小脑炎是异烟肼治疗中罕见的并发症。其发生通常与合并的肾脏疾病和血液透析有关。在此，我们报告一例出现这种并发症的患者，其磁共振成像显示孤立的双侧对称齿状核T2高信号。从未有报道称异烟肼神经毒性会导致双侧齿状核高信号，对此鉴别诊断较少，包括甲硝唑毒性。
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本文引用的文献
1
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Indian J Radiol Imaging. 2010 Aug;20(3):195-7. doi: 10.4103/0971-3026.69355.
2
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AJNR Am J Neuroradiol. 2007 Oct;28(9):1652-8. doi: 10.3174/ajnr.A0655. Epub 2007 Sep 20.
3
Wernicke's encephalopathy: unusual manifestation on MRI.韦尼克脑病：磁共振成像的异常表现
J Neurol. 2005 Dec;252(12):1550-2. doi: 10.1007/s00415-005-0886-9. Epub 2005 Jul 21.
4
MRI findings in acute cerebellitis.急性小脑炎的磁共振成像表现
Eur Radiol. 2004 Aug;14(8):1478-83. doi: 10.1007/s00330-004-2247-y. Epub 2004 Feb 13.
5
Isoniazid toxicity with cerebellar ataxia in a child.
CMAJ. 1993 Jan 1;148(1):49-50.
6
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Nephron. 1993;64(2):303-6. doi: 10.1159/000187331.
7
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