Liu Yi, Lin Chang-sheng, Zhang Ai-min, Song Hua, Fan Chang-chun
Department of Urology, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, 250031, China.
Tumour Biol. 2014 May;35(5):4719-25. doi: 10.1007/s13277-014-1617-6. Epub 2014 Jan 23.
The cytochrome P450 1B1 (CYP1B1) gene plays a key role in the metabolism of various carcinogens. The CYP1B1 Leu432Val polymorphism leads to leucine to valine substitution at codon 432. A lot of studies have shown that the CYP1B1 Leu432Val polymorphism was associated with urinary system cancers, especially prostate cancer. However, the results were still inconclusive. In this meta-analysis, by searching online databases and references of related reviews, we identified 17 eligible studies to assess the relationship between CYP1B1 Leu432Val polymorphism and urinary system cancers, including 7,783 cancer cases and 7,238 controls. By pooling all eligible studies, we found that the CYP1B1 Leu432Val polymorphism was not associated with overall urinary system cancers. However, in subgroup analyses, we found that the variant 432Val allele significantly increased the risk of prostate cancer (Val vs. Leu, odds ratio (OR) = 1.064, 95% confidence interval (CI) 0.981-1.154; Pheterogeneity = 0.002), while no association was found for bladder cancer (Val vs. Leu, OR = 0.942, 95% CI 0.853-1.041; Pheterogeneity = 0.504). No evidence of publication bias was found (Begg's test, P = 0.053; Egger's test, P = 0.073). In conclusion, based on 17 eligible studies, we found that the CYP1B1 Leu432Val polymorphism was associated with an increased risk of prostate cancer, while no association of bladder cancer was observed.
细胞色素P450 1B1（CYP1B1）基因在多种致癌物的代谢中起关键作用。CYP1B1 Leu432Val多态性导致第432位密码子处的亮氨酸被缬氨酸取代。许多研究表明，CYP1B1 Leu432Val多态性与泌尿系统癌症，尤其是前列腺癌有关。然而，结果仍无定论。在这项荟萃分析中，通过检索在线数据库和相关综述的参考文献，我们确定了17项符合条件的研究，以评估CYP1B1 Leu432Val多态性与泌尿系统癌症之间的关系，其中包括7783例癌症病例和7238例对照。通过汇总所有符合条件的研究，我们发现CYP1B1 Leu432Val多态性与总体泌尿系统癌症无关。然而，在亚组分析中，我们发现432Val变异等位基因显著增加了前列腺癌的风险（Val与Leu相比，比值比（OR）=1.064，95%置信区间（CI）0.981 - 1.154；P异质性=0.002），而未发现与膀胱癌有关联（Val与Leu相比，OR = 0.942，95% CI 0.853 - 1.041；P异质性=0.504）。未发现发表偏倚的证据（Begg检验，P = 0.053；Egger检验，P = 0.073）。总之，基于17项符合条件的研究，我们发现CYP1B1 Leu432Val多态性与前列腺癌风险增加有关，而未观察到与膀胱癌有关联。
