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低强度治疗性超声对大鼠胫骨诱导性骨折的影响。

The effect of low-intensity therapeutic ultrasound in induced fracture of rat tibiae.

作者信息

Fontes-Pereira Aldo José, Teixeira Renato da Costa, de Oliveira Antônio Jorge Barbosa, Pontes Roberto Waldesmand Farias, de Barros Rui Sérgio Monteiro, Negrão José Nazareno Cunha

机构信息

Universidade Federal do Rio de Janeiro - Rio de Janeiro, RJ, Brasil.

Universidade do Estado do Pará - Belém, PA, Brasil.

出版信息

Acta Ortop Bras. 2013 Jan;21(1):18-22. doi: 10.1590/S1413-78522013000100003.

Abstract

OBJECTIVE

To analyze the possible effects of low-intensity ultrasound on induced tibia fracture of rats in a dose commonly used in physical therapy treatments.

METHODS

Twenty male Wistar rats were divided into two groups with 10 animals each. In the ultrasound group (USG), the animals were submitted to bone fracture and treatment with therapeutic ultrasound (TUS). Ultrasonic parameters are: frequency of 1.0 MHz, intensity of 0.2 W/cm2, pulsed mode at 20%, applied in stationary form during 10 minutes on the fracture region, for five weeks. The control group (CG) was submitted to bone fracture but not treated with ultrasound.

RESULTS

The radiographies showed better consolidation in USG compared to CG. The statistical tests for alkaline phosphatase and serum calcium did not show significant difference between groups.

CONCLUSION

According to this study, TUS, applied with these parameters (not commonly used for bone therapy) accelerates bone healing, confirmed by radiography, yet the biochemical analysis was not conclusive. One reason for this inconsistency may have been some inadequacy of the biochemical protocol, currently under investigation. Level of Evidence II, Prospective comparative study.

摘要

目的

分析低强度超声以物理治疗常用剂量作用于大鼠诱导性胫骨骨折可能产生的影响。

方法

将20只雄性Wistar大鼠分为两组,每组10只。在超声组(USG)中,动物接受骨折并接受治疗性超声(TUS)治疗。超声参数为:频率1.0MHz,强度0.2W/cm²,脉冲模式为20%,以固定形式在骨折区域施加10分钟,持续五周。对照组(CG)接受骨折但未接受超声治疗。

结果

X线片显示USG组的骨痂形成比CG组更好。碱性磷酸酶和血清钙的统计学检验显示两组之间无显著差异。

结论

根据本研究,以这些参数(并非常用于骨治疗)应用的TUS可加速骨折愈合,X线片已证实,但生化分析尚无定论。这种不一致的一个原因可能是生化检测方案存在一些不足,目前正在对此进行研究。证据水平II,前瞻性对比研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32d4/3862013/7a9049fd5c9d/aob-21-18-g01.jpg

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