Meshikhes Abdul-Wahed N, Al-Garni Ayed A, Al-Momen Sami A, Al-Nahawi Mamdouh, Abu Subaih Jawad
Section of General and Minimally Invasive Surgery, Department of Surgery, King Fahad Specialist Hospital, Dammam, Eastern Province, Saudi Arabia.
Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam, Eastern Province, Saudi Arabia.
Am J Case Rep. 2014 Jan 10;15:7-12. doi: 10.12659/AJCR.889835. eCollection 2014.
Female, 32 FINAL DIAGNOSIS: Gastrintestinal Autonomic Nerve Tumor (GANT) Symptoms: anemia • anorexia • fatigue • fever • hearburn • nausea • weight loss
Rare disease.
Gastrointestinal autonomic nerve tumors (GANT) are extremely rare tumors that are related to gastrointestinal autonomic nervous plexuses. They are distinguished from stromal tumors by their unique ultrastructural features. Hence, their diagnosis is usually made on electron microscopy and immunohistochemical analyses. Although they are apparently slow-growing tumors, they run an aggressive clinical course and often associated with poor prognosis which eventually leads to death.
We report on a case of gastric GANT in a young female who was treated surgically by total gastrectomy. The disease, however ran an aggressive course with the development of distant (nodal, liver, lung, adrenal and musculo-skeletal) metastases two months after the radical resection.
We believe this could be the first reported case of adrenal and musculo-skeletal metastases from gastric GANT soon after the radical gastric resection.
女性，32岁
胃肠道自主神经肿瘤（GANT）
贫血、厌食、疲劳、发热、烧心、恶心、体重减轻
胃肠病学与肝病学
罕见病
胃肠道自主神经肿瘤（GANT）是极其罕见的肿瘤，与胃肠道自主神经丛有关。它们通过独特的超微结构特征与间质瘤相区分。因此，其诊断通常依靠电子显微镜检查和免疫组化分析。尽管它们显然生长缓慢，但临床病程凶险，常伴有预后不良，最终导致死亡。
我们报告一例年轻女性胃GANT病例，该患者接受了全胃切除术。然而，疾病进展迅速，根治性切除术后两个月出现远处（淋巴结、肝脏、肺、肾上腺和肌肉骨骼）转移。
我们认为这可能是首例根治性胃切除术后不久胃GANT出现肾上腺和肌肉骨骼转移的报道病例。
