Ojanguren I, Ariza A, Navas-Palacios J J
Department of Pathology, Hospital Germans Trias i Pujol, Barcelona, Spain.
Hum Pathol. 1996 Dec;27(12):1311-8. doi: 10.1016/s0046-8177(96)90343-3.
Gastrointestinal autonomic nerve tumor (GANT) is a specialized form of stromal neoplasm whose ultrastructural features support a myenteric plexus derivation and provide the basis for its diagnosis. GANT actual frequency, relationship to skeinoid fibers, and CD34 expression status are some of the controversial aspects of this entity. Out of 14 gastrointestinal stromal tumors gathered during a 1-year period, six (42%) instances were diagnosed as GANT by electron microscopic study of at least five ultrathin sections per case. Additionally, GANTs were immunohistochemically investigated with a panel of nine antibodies including CD34. Ultrastructurally, every GANT case showed diagnostic findings and evidence of skeinoid fibers, whereas immunohistochemically all except one were CD34 positive. Immunoreactivity for neuron-specific enolase, synaptophysin, and vimentin was a common occurrence as well. In conclusion, GANT seems to be more frequent than hitherto recognized, skenoid fibers are a regular feature of GANT, and a positive CD34 immunoreaction does not discriminate between GANT and other non-smooth muscle, non-schwannian neoplasms.
胃肠道自主神经肿瘤（GANT）是一种特殊类型的间质肿瘤，其超微结构特征支持肌间神经丛起源，并为其诊断提供依据。GANT的实际发病率、与束状纤维的关系以及CD34表达状态是该实体存在争议的一些方面。在一年时间内收集的14例胃肠道间质瘤中，通过对每例至少5个超薄切片进行电子显微镜研究，有6例（42%）被诊断为GANT。此外，还使用包括CD34在内的一组9种抗体对GANT进行了免疫组织化学研究。在超微结构上，每例GANT均显示出诊断性发现和束状纤维的证据，而在免疫组织化学方面，除1例外均为CD34阳性。神经元特异性烯醇化酶、突触素和波形蛋白的免疫反应性也很常见。总之，GANT似乎比迄今所认识的更为常见，束状纤维是GANT的一个常见特征，CD34免疫反应阳性并不能区分GANT与其他非平滑肌、非施万细胞瘤。
