Verma Vibha, Yu Qiming J, Connell Des W
Griffith School of Engineering, Griffith University, Nathan Campus, Brisbane, Queensland 4111, Australia.
Griffith School of Environment, Griffith University, Nathan Campus, Brisbane, Queensland 4111, Australia.
ISRN Toxicol. 2013 Dec 26;2013:230763. doi: 10.1155/2013/230763.
A model based on the concept of reduction in life expectancy (RLE model) as a result of long term exposure to toxicant has been developed which has normal life expectancy (NLT) as a fixed limiting point for a species. The model is based on the equation (LC50 = a ln(LT50) + b) where a and b are constants. It was evaluated by plotting ln LT50 against LC50 with data on organic toxicants obtained from the scientific literature. Linear relationships between LC50 and ln LT50 were obtained and a Calculated NLT was derived from the plots. The Calculated NLT obtained was in good agreement with the Reported NLT obtained from the literature. Estimation of toxicity at any exposure time and concentration is possible using the model. The use of NLT as a reference point is important since it provides a data point independent of the toxicity data set and limits the data to the range where toxicity occurs. This novel approach, which represents a departure from Haber's rule, can be used to estimate long term toxicity from limited available acute toxicity data for fish exposed to organic biocides.
基于长期接触有毒物质导致预期寿命缩短这一概念开发了一种模型（预期寿命缩短模型，即RLE模型），该模型将正常预期寿命（NLT）作为一个物种的固定极限点。该模型基于公式（LC50 = a ln(LT50) + b），其中a和b为常数。利用从科学文献中获取的有机毒物数据，通过绘制ln LT50与LC50的关系图对该模型进行了评估。得到了LC50与ln LT50之间的线性关系，并从这些图中得出了计算得到的NLT。得到的计算得到的NLT与从文献中获得的报告的NLT高度一致。使用该模型可以估计任何暴露时间和浓度下的毒性。将NLT用作参考点很重要，因为它提供了一个独立于毒性数据集的数据点，并将数据限制在发生毒性的范围内。这种新颖的方法与哈伯定律不同，可用于根据有限的现有急性毒性数据估算鱼类接触有机杀生物剂后的长期毒性。
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